Employment biologically active preparation “Surfakta ZKF” in prophylactic hypoxia fetus and treatment of calves

  • A. Zamaziy Poltava State Agrarian Academy, Poltava
  • M. Кambur Sumy National Agrarian University, Sumy
  • A. Кolechko Sumy National Agrarian University, Sumy
  • A. Lermontov Sumy National Agrarian University, Sumy
  • O. Butov Sumy National Agrarian University, Sumy
Keywords: correction, blood, deadly period, birth activity, amnion


The influence of “Surfakta ZKF”, got from amniotic fluid cows in prophylaxis hypoxia and treating calves born with signs asphyxia. Incurrence prevention fetus hypoxia of fetal development, contributed to the fact that the body weight calves received from cows research group appeared at birth at 3,90 ± 0,7 kg higher (16.25%) than in calves from cows controlling group “Immature” surfactant system lungs found in 30% calves cows control group (6 goals) and only two calves (10%) research group. Found that the complex of measures aimed at preventing the development of the fetus hypoxia genus promoted that of research group donetck only two calves (20%) from “immaturity” surfactant system lungs, but with signs of phospholipids one calf (10%), and in cows control group the first time we received from “immaturity” surfactant system lungs three calves (30%), but with signs of phospholipids two calves (20%). Treatment calves born with signs of phospholipids promoted (5-day) increase of partial pressure O2 in blood (first eight-goal Chelsea storm to fourth title – third group). In calves first group 2 blood during treatment has grown in 1.85 times and in animals two other research groups (the second and the third) PO2 increased in 1.91-1.56 times in comparison with this indicator after birth. The partial pressure CO2 in blood calves born with signs of hypoxia, declining in the process of treatment of time birth till 5-th day to 53,20 ± 3.02-57,80 ± 2.22 mm Hg compared with the first era life this indicator was at the 1.48-1,39 times lower (a < 0.01). Contents of СО2 in blood calves first is the third group has fluctuated from 30,40 ± 1,72 to 32,98 ± 0,95mmol/l, almost met the indication (31,54 ± 0,79 mmol/l) function active calves. Established that the 5-day life (treatment) blood in oxygen calves all groups increased in comparison with this indicator after birth. In reduced-active calves increase by 18,85%, while in calves first – third research group, by 21,00, received 13.04 percent and 6,97%. Unlike the first day, at 5-day life respiratory index function active  calves and calves born with signs of phospholipids was lower than in 1,26; 1,72;1.83 and 1,49 times (a < 0.01) and  only in 1.08 times in the calves controlling group. It is got net income on experience calves (first-third group) are 11258,80 grn, that on every calf presents for 450,35 grn. In a control group it is got net income in all 565,0 grn, and on one calf 62,77 grn., that in 7,17 below, this index of calves of experience groups.


Download data is not yet available.


Bochkov, V.N., Dobrovol'skij, A.B., Kushlinskij, N.E., Loginov, V.A., Ratnar, E.I., Tvorogova, M.G., Titov, V.N. & Tkachuk, V.A. (2004). Klinicheskaja biohimija [Clinical biochemistry]. GJeOTAR–MED, Moscow (in Russian).

Byrkun, A.A., Nesterov, E.N. & Kobozev, G.V. (1981). Surfaktant legkyh [Surfactant of the lungs]. Zdorov'e, Kyev (in Russian).

Cotten, C. M., Murtha, A. P., Goldberg, R. N., Grotegut, C. A., Smith, P. B., Goldstein, R. F., … Kurtzberg, J. (2014). Feasibility of Autologous Cord Blood Cells for Infants with Hypoxic-Ischemic Encephalopathy. The Journal of Pediatrics, 164(5), 973–979.

Escobar, J., Teramo, K., Stefanovic, V., Andersson, S., Asensi, M. A., Arduini, A., … Vento, M. (2013). Amniotic Fluid Oxidative and Nitrosative Stress Biomarkers Correlate with Fetal Chronic Hypoxia in Diabetic Pregnancies. Neonatology, 103(3), 193–198.

Giussani, D. A., & Davidge, S. T. (2013). Developmental programming of cardiovascular disease by prenatal hypoxia. Journal of Developmental Origins of Health and Disease, 4(05), 328–337.

Giussani, D. A., Spencer, J. A., & Hanson, M. A. (1994). Fetal cardiovascular reflex responses to hypoxaemia. Fetal and Maternal Medicine Review, 6(01), 17.

Hammond, E. M., Asselin, M.-C., Forster, D., O’Connor, J. P. B., Senra, J. M., & Williams, K. J. (2014). The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the Clinic. Clinical Oncology, 26(5), 277–288.

Kane, A. D., Herrera, E. A., Hansell, J. A., & Giussani, D. A. (2012). Statin treatment depresses the fetal defence to acute hypoxia via increasing nitric oxide bioavailability. The Journal of Physiology, 590(2), 323–334.

Kane, A. D., Hansell, J. A., Herrera, E. A., Allison, B. J., Niu, Y., Brain, K. L., … Giussani, D. A. (2013). Xanthine oxidase and the fetal cardiovascular defence to hypoxia in late gestation ovine pregnancy. The Journal of Physiology, 592(3), 475–489.

Kryshtoforova, B.V. Lemeshhenko, V.V. & Stegnej, Zh.G. (2007). Biologichni osnovy veterynarnoi' neonatologii' [Biological aspects of veterinary neonatology]. Terra Tavryka, Simferopol' (in Ukrainian).

Kachenjuk, Ju. A. (2006). Prenatal'na diagnostyka i korekcija patologichnogo stanu ploda (klinichni aspekty, mozhlyvosti i perspektyvy). Extended abstract of Doctors thesis. K., 2006. – 32 s.

Li, H. P., Chen, X., & Li, M. Q. (2013). Gestational diabetes induces chronic hypoxia stress and excessive inflammatory response in murine placenta. International Journal of Clinical and Experimental Pathology, 6, 650–659.

Marshall, J. M. (1999). The Integrated Response to Hypoxia: From Circulation to Cells. Experimental Physiology, 84(3), 449–470.

Makarov, O.V., Koval'chuk, L.V., Gankovskaja, L.V., Bahareva, Y.V., Taranec, A.N. (2003). Dyagnostycheskoe znachenye yssledovanyja amnyotycheskoj zhydkosty pry vnutryutrobnom ynfycyrovanyy. Akusherstvo y gynekologyja, 4, 3 – 4.

Olcina, M. M., Grand, R. J., & Hammond, E. M. (2014). ATM activation in hypoxia - causes and consequences. Molecular & Cellular Oncology, 1(1), e29903.

Papajan, A.V. & Papajan, Y.S. (2002). Neonatal'naja nefrologyja: rukovodstvo. Pyter, SPb (in Russian).

Radzynskyj V.E. & Mylovanov, A.P. (2004). Jekstrajembrional'nye i okoloplodnye struktury pri normal'noj i oslozhnennoj beremennosti. MYA, Moscow (in Russian).

Semenza, G. L. (2012). Hypoxia-Inducible Factors in Physiology and Medicine. Cell, 148(3), 399–408.

Shah, N. N., Shah, H., & Paris, K. (2014). A Rare Presentation Of Surfactant Deficiency In a Term Neonate. Journal of Allergy and Clinical Immunology, 133(2), AB1.

Soria, R., Julian, C. G., Vargas, E., Moore, L. G., & Giussani, D. A. (2013). Graduated effects of high-altitude hypoxia and highland ancestry on birth size. Pediatric Research, 74(6), 633–638.

Thyagarajan, B., Tillqvist, E., Baral, V., Hallberg, B., Vollmer, B., & Blennow, M. (2014). Minimal enteral nutrition during neonatal hypothermia treatment for perinatal hypoxic-ischaemic encephalopathy is safe and feasible. Acta Paediatrica, 104(2), 146–151.

Thakor, A. S., Allison, B. J., Niu, Y., Botting, K. J., Serón-Ferré, M., Herrera, E. A., & Giussani, D. A. (2015). Melatonin modulates the fetal cardiovascular defense response to acute hypoxia. Journal of Pineal Research, 59(1), 80–90.

Tyler, H., & Ramsey, H. (1991). Hypoxia in Neonatal Calves: Effect on Selected Metabolic Parameters. Journal of Dairy Science, 74(6), 1957–1962.

Zamazij, A.A. (2008). Zhyrnokyslotnyj sklad navkoloplidnyh ridyny funkcional'noaktyvnyh novonarodzhenyh tvaryn. Visnyk Sums'kogo NAU, 5(20), 42–45 (in Ukrainian).

Zamazij, A.A., & Kambur, M.D. (2006). Transformacija deponovanoi' energii' na produkciju u koriv i i'i' vplyv nazrilist' surfaktantno – al'veoljarnoi' systemy novonarodzhenyh teljat. Visnyk Sums'kogo NAU, 1 (2), 61 – 63 (in Ukrainian).

Abstract views: 129
PDF Downloads: 67
How to Cite
Zamaziy, A., КamburM., КolechkoA., Lermontov, A., & Butov, O. (1). Employment biologically active preparation “Surfakta ZKF” in prophylactic hypoxia fetus and treatment of calves. Theoretical and Applied Veterinary Medicine, 5(4), 45-55. Retrieved from https://bulletin-biosafety.com/index.php/journal/article/view/162