NATURAL INDICATORS OF SAFETY QUALITY OF NANOMATERIALS

  • V. Kovalenko Institute of Veterinary Medicine of National Academy of Ukraine, Kyiv
  • G. Ponomarenko Kharkov State Zooveterinary Academy, Kharkov
  • O. Ponomarenko Kharkov State Zooveterinary Academy, Kharkov
  • A. Zagrebelnyi National Research Institute for laboratory diagnostics and veterinary-sanitary examination, Kyiv
  • T. Bovkun ТОВ “НВП “Екологічний Капітал”, м. Київ
  • V. Kunitsky OOO «NPP «Bristol-Farm», Kyiv
Keywords: nanoparticles, nanomaterials, toxicology, bees, bacteria, ecology.

Abstract

This article provides information about the impact of different chemical compounds and nanomaterials used  for the development of advanced materials- implements and medicines.   Peroral influence of nanoparticles is one of the ways of getting to animals and bees. Peroral influence possi- ble in the case of food contamination nanoparticles, carrying nanoparticles in the mouth from the skin and, fi- nally, by  peroral medications, which are based on  nanoparticles. Although  absorption of nanoparticles in  the  gastrointestinal tract is slight,  most  studies have shown that peroral  administration  accompanied by some in- crease in their levels of plasma.   It is known that nanoparticles measure absorption in the gastrointestinal tract depends on the size and charac- teristics of the surface and the small, neutral hydrophobic nanoparticles are absorbed better than large and hy- drophilic.  There are two possible ways of transport of nanomaterials, when they enters the digestive tract - active and  passive. The nanoparticles is capable to bind heavy metals, pesticides, poisons soluble in liquids and deliver them  into the body. From the small intestine nanoparticles get into the blood (passing the epithelial barrier, or through  the mechanism of endocytosis). In addition, through the formation of free radicals and reactive oxygen species  nanoparticles can  cause lipid  peroxidation  in  cells, denaturation  of proteins  and  nucleic acids  damage. This  leads to a decrease in cell viability, followed by physiological, biochemical, morphological (ultrastructural, his- tochemical) changes. Nanoparticles can penetrate the skin from air, water, materials from which made household  items. Nanoparticles have local resorptive effect on covers and thus enter the bloodstream and lymphatic system.  Also,  because  of  the  high  binding capacity  they are  able to protect  sorbents  of  toxic  action  of  enzymes  skin.  Therefore it is recommended to use bees as indicators of ecology exhaust to determine the toxic effects of sub- stances.

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Author Biographies

V. Kovalenko, Institute of Veterinary Medicine of National Academy of Ukraine, Kyiv
д. вет. н.
G. Ponomarenko, Kharkov State Zooveterinary Academy, Kharkov
к. вет. н., доцент
O. Ponomarenko, Kharkov State Zooveterinary Academy, Kharkov
к. вет. н.
T. Bovkun, ТОВ “НВП “Екологічний Капітал”, м. Київ
OOO «NPP «Environmental Capital», Kyiv
V. Kunitsky, OOO «NPP «Bristol-Farm», Kyiv
директор

References

Концепція розробки та використання ко мплексних дезінфектантів дл я ветеринарної медицини: Монографія / За ред. В. Л. Коваленка, В. В. Недосєкова. – К.: НУБіП України, 2011. – 146 с.

Нанотехнологии в биологии и медицине. Коллективная монография / Под ред. чл.- корр. РАМН, проф. Е. В. Шляхто. – М.: – 2009. – 250 с.

Шакиров Д. Т. Словарь – справочник пчеловода / Д. Т. Шакиров. – Уфа, –1998. – 150 с.

Нанотоксикологія: напрямки досліджень (огляд). / Чекман І.С., Сердюк А.М., Кундієв Ю.І. та ін. / Довкілля та здоров’я, – 2009. – 1(48): С. 3–7.

Чекман І.С. Наноматеріали і наночастинки: класифікація. / І.С. Чекман, Н.О. Горчакова, О.Ю. Озейчук / Наук. вісн. Нац. мед. ун-ту ім. О.О. Богомольця, 2: – 2009. – С. 188– 201.

Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro / R. Colognato, A. Bonelli, J. Ponti et al. // Mutagenesis: – 2008. – № 23 (5) – Р. 377–382.

Ferrari M. Cancer nanotechnology: opportunities and challenges / M. Ferrari // Nat. Rev. Cancer: – 2005. – № 5 (3) – Р. 161– 171.

Sahoo S. K. The present and future of nanotechnology in human health care / S.K. Sahoo, S. Parveen, J. J. Panda // Nanomedicine: – 2007. – № 3(1) – Р. 20–31.

Donaldson K. An introduction to the short- term toxicology of respirable industrial fibres / K. Donaldson, C. L. Tran // Mutat. Res: ‒ 2004. – № 553 (1–2) – Р. 5–9.

Москаленко В. Ф. Екологічні і токсиколого-гігієнічні аспекти біологічної безпеки нанотехнологій, наночастинок та наноматеріалів / В.Ф. Москаленко, О.П. Яворовський // Наук. вісн. Нац. мед. ун-ту ім. О.О. Богомольця, 3: – 2009. – С. 25–35.

Sayes C.M. Assessing toxicity of fine and nan oparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles / C.M. Sayes, K.L. Reed, D.B. Warheit / Toxicology Science: – 2007. – № 97 (1) – Р. 163–180.


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How to Cite
Kovalenko, V., Ponomarenko, G., Ponomarenko, O., Zagrebelnyi, A., Bovkun, T., & Kunitsky, V. (1). NATURAL INDICATORS OF SAFETY QUALITY OF NANOMATERIALS. Theoretical and Applied Veterinary Medicine, 4(3), 13-18. Retrieved from https://bulletin-biosafety.com/index.php/journal/article/view/27