Therapeutic efficacy of Akarostop for dogs and cats against acariform mite

Keywords: amitraz; sarcoptic mange; notoedrosis; otodectosis


This article is devoted to the study of the effectiveness of the preparation, namely Akarostop, with the active substance amitraz and the excipient dimethyl sulfoxide. The research was conducted with the involvement of pets kept in the private sector and housing (dogs and cats). All research results were controlled by observation of the clinical condition of animals and microscopy of scrapings from the affected areas of the skin and ears. The presence of live mites was determined by lightly warming up the slide. The effectiveness of the drug against sarcoptic mange was established in the treatment of 13 dogs, which were treated once a day with a 3 days interval. Clinical signs of the disease began to resolve in 5–9 days after the first application of the drug, which was manifested by the disappearance of hyperemia, a decrease in exudation, and crusting. The efficiency after two treatments was 40%. On the 21st day before applying the drug, single inactive ticks were found in 5 out of 13 animals in their skin scrapes. The efficacy of the drug against Notoedres in cats was determined, which were treated once a day with a 3 days interval. After 8 days of the treatment in cats' skin scrapings, dead mites and single live ones were found, and on the 13th day crusts dried out, fell away, skin became pale pink and dry. The recovery of animals was observed gradually: on the 13th day it amounted to 33%, on the 17th day – 55%, and residually on the 21st day. Thus, the 100% therapeutic efficacy of the drug Acarostop has been established for the five-time treatment of cats against Notoedres. The efficacy of the preparation for otodectosis of dogs and cats was determined by applying 2–3 drops of the drug into the cleaned ear. Clinical signs of the disease 3–4 days after the first application of the drug began to disappear, which was manifested by the disappearance of hyperemia, a decrease in exudation, falling off crusts, and the absence of itching. On days 5 to 9 from the beginning of treatment all animals recovered, which was confirmed by clinical and laboratory tests. After the tests, the animals continued to be observed and no relapses were found within 4 weeks. In the future, we plan to conduct research on an acaricidal preparation with an improved composition and effect, namely, antipruritic, anti-inflammatory and regenerating effect.


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Akucewich, L. H., Philman, K., Clark, A., Gillespie, J., Kunkle, G., Nicklin, C. F., & Greiner, E. C. (2002). Prevalence of ectoparasites in a population of feral cats from north central Florida during the summer. Veterinary Parasitology, 109(1-2), 129–139.

Alvarado-Esquivel, C., Romero-Salas, D., Aguilar-Domínguez, M., Cruz-Romero, A., Ibarra-Priego, N., & Pérez-de-León, A. Á. (2015). Epidemiological assessment of intestinal parasitic infections in dogs at animal shelter in Veracruz, Mexico. Asian Pacific Journal of Tropical Biomedicine, 5(1), 34–39.

Antipov, A. A., Honcharenko, V. P., & Dzhurynskyi, O. M. (2013). Efektyvnist Vermiku 1%-noho inʼiektsiinoho rozchynu za kyshkovykh nematodoziv svynei [The effectiveness of injectionales solution 1% Vermik by the treatment of mixed intestinal nematodosis of pigs]. Scientific journal of veterinary medicine, 11(101), 11–14 (in Ukrainian).

Bakhur, T. I., & Poberezhets, S. P. (2016). Changes in hematological indices of cats with notoedrosis and as result of treatment in different ways. Scientific Messenger of LNU of Veterinary Medicine and Biotechnology, 18(2(66)), 3–8 (in Ukrainian).

Burrows, A. (2000). Generalised demodicosis in the dog: the unresponsive or recurrent case. Australian Veterinary Journal, 78(4), 244–246.

Dubova, O. A., Zghozinska, O. A., & Dubovyi, A. A. (2019). Epizootic features of pets’ sarcoptoidoses and therapeutic efficiency of iver-mectin. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies, 21(96), 3–7 (in Ukrainian).

Filazi, A., & Yurdakok-Dikmen, B. (2018). Amitraz. Veterinary Toxicology, 525–531.

Folz, S. D., Kakuk, T. J., Henke, C. L., Rector, D. L., & Tesar, F. B. (1984). Clinical evaluation of amitraz as a treatment for canine demodicosis. Veterinary Parasitology, 16(3-4), 335–341.

Heaney, K., & Lindahl, R. G. (2007). Safety of a topically applied spot-on formulation of metaflumizone plus amitraz for flea and tick control in dogs. Veterinary Parasitology, 150(3), 225–232.

Iken, I., Abdessadek, M., El Attari, A., & Achour, S. (2020). Poisoning by Amitraz, uncommon pesticide revealed by high performance liquid chromatography: About two cases. Toxicologie Analytique et Clinique, 32(3), 200–204.

Ivkin, D. Yu., Okovity, S. V., Ivkina, A. S., & Anisimova, N. A. (2019). Dimethyl sulfoxide: a substance with pleiotropic effects actual in musculoskeletal diseases. Lechashchyi Vrach, 4, 19–22 (in Russian).

Jakubovskij, M. V., & Karasev, N. F. (2001). Diagnostika, terapija i profilaktika parazitarnyh boleznej zhivotnyh [Diagnostics, therapy and prevention of parasitic diseases of animals]. Minsk. Hata (in Russian).

Jatusevich, A. I. Rachkovskaja, I. V., & Kaplich, V. M. (2001). Veterinarnaja i medicinskaja parazitologija: Jenciklopedicheskij spravochnik [Veterinary and Medical Parasitology: An Encyclopedic Reference]. Moskva. Medicinskaja literatura (in Russian).

Jonsson, N. N., & Hope, M. (2007). Progress in the epidemiology and diagnosis of amitraz resistance in the cattle tick Boophilus microplus. Veterinary Parasitology, 146(3-4), 193–198.

Lefkaditis, M. A., Koukeri, S. E., & Mihalca, A. D. (2009). Prevalence and intensity of Otodectes cynotis in kittens from Thessaloniki area, Greece. Veterinary Parasitology, 163(4), 374–375.

Medvedev, K. S. (1999). Bolezni kozhi sobak i koshek. Kyiv. Vima (in Russian).

Page, S. W. (2008). Antiparasitic drugs. Small Animal Clinical Pharmacology, 198–260.

Perego, R., Proverbio, D., Bagnagatti De Giorgi, G., Della Pepa, A., & Spada, E. (2013). Prevalence of otitis externa in stray cats in northern Italy. Journal of Feline Medicine and Surgery, 16(6), 483–490.

Petermann, J., Cauquil, L., Hurlin, J. C., Gaia, H., & Hüe, T. (2016). Survey of cattle tick, Riphicephalus (Boophilus) microplus, resistance to amitraz and deltamethrin in New Caledonia. Veterinary Parasitology, 217, 64–70.

Raether, W., & Hänel, H. (2003). Epidemiology, clinical manifestations and diagnosis of zoonotic cestode infections: an update. Parasitology Research, 91(5), 412–438.

Six, R. H., Becskei, C., Mazaleski, M. M., Fourie, J. J., Mahabir, S. P., Myers, M. R., & Slootmans, N. (2016). Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis. Veterinary Parasitology, 222, 62–66.

Sotiraki, S., Koutinas, A., Leontides, L., Adamama-Moraitou, K., & Himonas, C. (2001). Factors affecting the frequency of ear canal and face infestation by Otodectes cynotis in the cat. Veterinary Parasitology, 96(4), 309–315.

Traversa, D. (2012). Pet roundworms and hookworms: A continuing need for global worming. Parasites & Vectors, 5(1).

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How to Cite
Sapko, S. A. (2020). Therapeutic efficacy of Akarostop for dogs and cats against acariform mite. Theoretical and Applied Veterinary Medicine, 8(3), 198-201.