Colostral immunity of piglets to the Aujeszky disease virus in case of active immunization sows

Keywords: Aujeszky’s disease; immunoglobulins G (IgG) to glycoproteins E (gE) and B (gB); pigs; vaccination; serological control; enzyme-linked immunosorbent assay; colostrum

Abstract

The current question of today is the formation of effective immune protection in young pigs against infectious diseases, achieved by piglets vaccination in the first weeks of their life. It is known that one of the factors influencing the quality of vaccination is colostral antibodies, which are able to deactivate the vaccine antigen. Considering this, it is important to determine the duration of colostral immunity of piglets to antigens of the Aujeszky’s disease virus during active sows immunization. For this, was formed a group of sows of 2nd-3rd gestation periods with 25 animals in each. Sows were immunized parenterally against Aujeszky’s disease with the «Adivak» vaccine at a dose of 2 ml, by mass vaccination, three times per year. The level of specific antibodies to glycoproteins E (gE) and B (gB) was determined in the blood serum of piglets before sucking colostrum and every 7 days of life until 77 days from birth by enzyme-linked immunosorbent assay (ELISA). It was revealed that before consuming colostrum, piglets did not have specific antibodies to the antigens of the Aujeszky disease virus. From 7th till 70th days of life, all piglets had specific IgG to the antigens gB and gE of the Aujeszky disease virus, and by the seventy-seventh day, 29% of the animals were seronegative. Thus, newborn piglets before colostrum suckling do not have specific immune protection against the Aujeszky disease virus against the background of sow immunization. Consumption of colostrum by piglets promotes their formation of colostral immunity, specific to the antigens of the Aujeszky disease virus. The duration of colostral antibodies’ circulation specific to the antigens of the Aujeszky disease virus in the piglets peripheral blood is 70 days. On the seventy-seventh day from birth, the level of colostral immunoglobulins decreased sharply, which contributed to the appearance of seronegative animals and an increase in their sensitivity to the action of an epizootic strain of the virus.

Downloads

Download data is not yet available.

References

Bertasoli, B. M., Santos, A. C., Paula, R. S., Barbosa, A. S., Silva, G. A. B., & Jorge, E. C. (2015). Swine placenta and placentation. Brazilian Journal of Biological Sciences, 2(4), 199–207.

Bertran, K., Lee, D.-H., Criado, M. F., Balzli, C. L., Killmaster, L. F., Kapczynski, D. R., & Swayne, D. E. (2018). Maternal antibody inhibition of recombinant Newcastle disease virus vectored vaccine in a primary or booster avian influenza vaccination program of broiler chickens. Vaccine, 36(43), 6361–6372.

Brambell, F. W. R. (1970). The transmission of passive immunity from mother to young. North Holland Research Monographs Frontiers of Biology, 18.

Brandtzaeg, P. (2010). The mucosal immune system and its integration with the mammary glands. The Journal of Pediatrics, 156(2), 8–15.

Choe, S., Shin, J., Kim, K.-S., Song, S., Cha, R. M., Jung, B.-I., Hyun, B.-H., Park, B.-K., & An, D.-J. (2020). Protection of piglets with maternally derived antibodies from sows inoculated with an attenuated live marker Classical Swine Fever vaccine (Flc-LOM-BErns). Pathogens, 9(8), 608.

Chung, E. L. T., Alghirani, M. M., Kamalludin, M. H., Nayan, N., Jesse, F. F. A., Wei, O. T. A., Stephen, M. A. F. M. H., Reduan, M. F. H., & Loh, T. C. (2020). Do different vaccination regimes affect the growth performance, immune status, carcase characteristics and meat quality of broilers? British Poultry Science, 1–6.

Elahi, S., Buchanan, R. M., Babiuk, L. A., & Gerdts, V. (2006). Maternal immunity provides protection against pertussis in newborn piglets. Infection and immunity, 74(5), 2619–2627.

Esposito, F., Lombardi, S., Modiano, D., Zavala, F., Reeme, J., Lamizana, L., Coluzzi, M., & Nussenzweig, R. S. (1988). Prevalence and levels of antibodies to the circumsporozoite protein of Plasmodium falciparum in an endemic area and their relationship to resistance against malaria infection. Transactions of the Royal Society of Tropical Medicine and Hygiene, 82(6), 827–832.

Hasan, S., Orro, T., Valros, A., Junnikkala, S., Peltoniemi, O., & Oliviero, C. (2019). Factors affecting sow colostrum yield and composition, and their impact on piglet growth and health. Livestock Science, 227, 60–67.

Jalil, A. R., Hayes, B. H., Andrechak, J. C., Xia, Y., Chenoweth, D. M., & Discher, D. E. (2020). Multivalent, soluble nano-self peptides increase phagocytosis of antibody-opsonized targets while suppressing “Self” signaling. ACS Nano, 14(11), 15083–15093.

Kielland, C., Rootwelt, V., Reksen, O., & Framstad, T. (2015). The association between immunoglobulin G in sow colostrum and piglet plasma1. Journal of Animal Science, 93(9), 4453–4462.

Langel, S. N., Paim, F. C., Lager, K. M., Vlasova, A. N., & Saif, L. J. (2016). Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): Historical and current concepts. Virus Research, 226, 93–107.

Poonsuk, K., & Zimmerman, J. (2017). Historical and contemporary aspects of maternal immunity in swine. Animal Health Research Reviews, 19(1), 31–45.

Quesnel, H., Farmer, C., & Devillers, N. (2012). Colostrum intake: Influence on piglet performance and factors of variation. Livestock Science, 146(2-3), 105–114.

Riber, U., Heegaard, P. M., Cordes, H., Ståhl, M., Jensen, T. K., & Jungersen, G. (2015). Vaccination of pigs with attenuated Lawsonia intracellularis induced acute phase protein responses and primed cell-mediated immunity without reduction in bacterial shedding after challenge. Vaccine, 33(1), 156-162.

Robinson, K. E., & Mahony, T. J. (2020). The construction and evaluation of Herpesvirus vectors. Viral Vectors in Veterinary Vaccine Development, 95–110.

Sedeik, M., El-shall, N., Awad, A., Abd El-Hack, M., Alowaimer, A., & Swelum, A. (2019). Comparative evaluation of HVT-IBD vector, immune complex, and live IBD vaccines against vvIBDV in commercial broiler chickens with high maternally derived antibodies. Animals, 9(3), 72.

Theil, P. K., & Hurley, W. L. (2016). The protein component of sow colostrum and milk. Milk proteins - from structure to biological properties and health aspects.

Kokarev, A., & Masiuk, D. (2017). Formation mechanisms of immune cells protection in pigs under the influence of «Imunolak». Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 19(77), 214–219.

Abstract views: 165
PDF Downloads: 119
Published
2020-11-27
How to Cite
Holda, K. O., Masiuk, D. M., Kokariev, A. V., & Vasilenko, T. O. (2020). Colostral immunity of piglets to the Aujeszky disease virus in case of active immunization sows. Theoretical and Applied Veterinary Medicine, 8(4), 257-260. https://doi.org/10.32819/2020.84037