Haematological changes in laboratory rats with Ibuprofen-induced gastric ulcer treated with Humilid

Keywords: humic supplement treatment; blood indicators; blood cell count; white blood cells fractions


Changes in the complete blood cell count (CBC) due to the action of various medical substances are a common phenomenon. Nonsteroidal anti-inflammatory drugs (NSAIDs) are no exception. Ibuprofen, as the NSAID representative, may not only cause the formation of a gastric ulcer but also causes significant changes in the blood’s morphological parameters, hence disrupting systemic homeostasis. The results of the effect of Humilid on the restoration and normalization of haematological parameters in Ibuprofen-induced gastric ulcers in laboratory rats are presented. During the study, which lasted 21 days, it was found that on the third day of the experiment, Ibuprofen in the amount of 400 mg/kg of body weight caused microcytic hypochromic anaemia, thrombocytopenia, leukopenia with neutrophilia, lymphocytopenia and monocytopenia. On the 21st day of the experiment, in the group of animals where Humilid (5 mg/kg) was used after Ibuprofen-induced gastric ulcers, the haemoglobin content was 11% higher than in the rats of the group where Humilid was not used and 23% higher (p<0.001) compared to the beginning of the experiment. It was established that in the case of Ibuprofen-induced gastric ulcer, supplementing the diet of experimental animals with Humilid promotes recovery of erythrocytes, increase in haemoglobin concentration, increase in blood oxygen capacity, as well as normalization of platelet and leukocyte numbers that can be explained by antioxidant, adaptogenic, and membrane-stabilizing properties of humic substances.


Download data is not yet available.

Abstract views: 27
PDF Downloads: 24
How to Cite
Lisna, A. Y., & Stepchenko, L. M. (2022). Haematological changes in laboratory rats with Ibuprofen-induced gastric ulcer treated with Humilid. Theoretical and Applied Veterinary Medicine, 10(2), 15-22. Retrieved from https://bulletin-biosafety.com/index.php/journal/article/view/335