POISONING DOGS ISONIAZID IN THE CITY OF DNІPROPETROVSK

  • M. Shestakova Dnipropetrovsk State Agrarian and Economic University, Dnipropetrovsk
  • N. Shkvarya Dnipropetrovsk State Agrarian and Economic University, Dnipropetrovsk
Keywords: dogs, poisoning, isoniazid, metoclopramide, nonsteroidal anti-inflammatory drugs, paracetamol.

Abstract

 Background: Intoxication of dogs with isoniazid is more likely to occur due to the fact that they often choose food in the street, so become an easy target for doghunters specifically disperse toxic baits. In some cases, the poisoning can result from accidental use of isoniazid or an overdose of metoclopramide, paracetamol ornonsteroidal anti-inflammatory drugs, but such cases are very rare. The cause of poisoning in dogs is isoniazid.Objective:determining the efficacy of a complex isoniazid poisoning treatment in dogs.Methods:The study focused on 20 dogs of various breeds with signs of intoxication. The work was performed as follows: anamnestic data collection; Clinical study of animals; Laboratory examination of blood and urine; chemical - toxicological examination vomit or stomach contents for the presence of isoniazid; in the case of death of the animal to the implementation of the anatomo-pathological dissection;the differential diagnosis of poisoning isoniazid other diseases; Experimental and clinical study of efficacy of treatment of poisoning dogs is isoniazid or combinations with other drugs (metoclopramide, Masteron inflammatory drugs, acetaminophen); comparing the clinical efficacy of poisoning by isoniazid treatment and its combinations with other drugs.Results:nineteen dogs survived and recovered in twenty. Animal fourth group (isoniazid toxicity, metoclopramide and paracetamol) were killed. The pathological changes observed at autopsy were consistent with poisoning isoniazid, metoclopramide and paracetamol. The results of chemical and toxicological studies have confirmed the presence of isoniazid in the contents of the stomach of the animal.Each animal of the four groups during treatment and after the end of his regularly performed a clinical examination on the basis of which it can be stated that the general condition of all animals after treatment is good, they have improved appetite, increased reaction to external stimuli, there was a curiosity about the world. In the basic study of morphological and biochemical parameters of the blood of dogs subjected to treatment were identified indices normalization process of what was abnormal before treatment.Conclusion:it is established that the most common cause of poisoning in dogs isoniazid are the dog hunters or utilities; our studies have shown a high frequency of poisoning in dogs isoniazid in Dnepropetrovsk and negative changes in morphological and biochemical blood indices; tested and proven high effectiveness in treatment of dogs a specific antidote of isoniazid – pyridoxine (vitamin B6).

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Author Biographies

M. Shestakova, Dnipropetrovsk State Agrarian and Economic University, Dnipropetrovsk
студентка
N. Shkvarya, Dnipropetrovsk State Agrarian and Economic University, Dnipropetrovsk
к. вет. н., доцент

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How to Cite
Shestakova, M., & Shkvarya, N. (1). POISONING DOGS ISONIAZID IN THE CITY OF DNІPROPETROVSK. Theoretical and Applied Veterinary Medicine, 4(2), 29-34. Retrieved from https://bulletin-biosafety.com/index.php/journal/article/view/5