TY - JOUR AU - V. Sentiurin AU - R. Komsheliuk PY - 1970/01/01 Y2 - 2024/03/28 TI - THE EFFECT OF PROBIOTICS "VETOM 2" ON INDEX OF CALVES' NATURAL RESISTANCE JF - Theoretical and Applied Veterinary Medicine JA - TAVM VL - 5 IS - 1 SE - Veterinary Morphology and Pathology DO - UR - https://bulletin-biosafety.com/index.php/journal/article/view/75 AB - For research was formed three groups of calves 30 days old with 5 animals in each: two research groups and control one. Calves from the first experimental group have got “Vetom 2” with food at a dose of 75 mg per 1 kg 1 time a day for 5 days. Calves from the second group were given 50 mg per 1 kg of body weight 2 times a day for 5 days. In the control group drugs for calves was not used. After 28 days of the experiment leukocyte level of the animals’ blood from the first experimental group was higher than the benchmarks by 11.4 compared with the control, and the number of red blood cells and hemoglobin higher respectively by 5.1 and 9.8%. Level of white blood cells, red blood cells and hemoglobin of animals from second experimental group during this period were higher compared to similar control by 3.4; 4.2 and 5.2%. After using of the drug in research groups content of total protein indicators of blood exceeded the control group animals: in the first group to 14.6%; in the second group - 13.7%. The content of albumin in the blood serum of experimental animals in the first and the second groups after using of the drug was higher than in the control group after watering the preparation, respectively, 10.6 and 9.3%. Content ά-globulins in blood serum of calves from the first and the second research group at the end of the experiment was lower than control index respectively 17.5% and 20.9%. The content of β-globulins in blood serum of animals from the first and the second group during this period was higher compared with control respectively by 9.4 and 10.24%. Calves from first and second experimental groups compared with similar control shows tendency to increase γ-globulins respectively 42.3 and 43.91%. After using of “Vetom 2” the phagocytic activity of leukocytes of the animals from the first and the second group was significantly higher respectively by 17.3 and 16.0% than in the control group animals. There also have been higher phagocytic number of calves’ blood from research groups, which according to stock the first and second groups in 1.16 and 1.12 times higher than the control parameters. Serum bactericidal activity of animals from first and second experimental group was significantly higher than in control counterparts, respectively, 6.28% and 3.0%. Lysozyme activity of serum of animal from research groups throughout the experiment, with varying degrees of reliability was higher than in the control group of calves. In the first experimental group of calves recorded a significant increase of lysozyme activity compared to controls by 40.6%. The animals of the second experimental group had lysozyme activity of serum exceed analogue control, respectively, 25.16%. “Vetom 2” has stimulating effect on the humoral and cellular immunity, thus increasing lysozyme bactericidal activity and serum. Thus, the “Vetom 2” reveals immunomodulating effect and increases the nonspecific resistance of calves within physiological features and their resistance to adverse environmental factors. ER -